This dataset consists of multiple products derived from eco-hydrologic, statistical, and water supply routing models used to determine water supply vulnerability to hydrologic change within the Research Triangle of North Carolina, USA. The products are as follows: (1) eco-hydrologic modeling (SWAT and RHESSys models) products providing water availability estimates at the outlets of watersheds in the greater Research Triangle region, as well as precipitation and evaporation estimates for regional water supply reservoirs, projecting from 2010-2069, which were used to develop synthetic stochastic hydrology for further water supply modeling; (2) products of stochastic hydrology development to generate synthetic reservoir inflows based on eco-hydrologic modeling results for regional reservoirs, timeseries from 2015-2060, which are split into .tar repositories of (a) demands (b) inflows and (c) evaporation; (3) results from water supply management modeling used for results and visualization in related research publications.